What are Growth Factors?

A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. Usually it is a secreted protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes.

In articular cartilage, numerous growth factors work in concert to regulate development and homeostasis of articular cartilage throughout life. Therefore, growth factors offer promising treatments for enhanced regeneration of cartilage in focal articular cartilage defects or in situations of more widespread cartilage loss such as those which occur in osteoarthritis (OA). When considering an injured or osteoarthritic joint, the effects of any treatment such as growth factors on the cartilage, synovial lining, ligaments, tendons, meniscus, any exposed subchondral bone as well as on mesenchymal stem cells (MSCs) which gain access to the articular environment should be collectively considered.

Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells.

They often promote cell differentiation and maturation, which varies between growth factors. For example, epidermal growth factor (EGF) enhances osteogenic differentiation.

Osteoarthritis causes pain, activity limitation, physical disability and reduced health-related quality of life. This pain is usually treated with over-the-counter pain relievers, anti-inflammatory drugs, local steroid injections and sometimes surgery. There are currently no drugs approved to treat the underlying cause of the condition, which results from the breakdown of joint cartilage covering the long bones due to increasing age, injury/overuse, obesity, genetics and/or local inflammation.

Growth Factor therapy can help prevent a worsening of osteoarthritis by increasing the thickness of cartilage in the affected joint and preventing further loss, according to results from an early clinical trial that were published in the Journal of the American Medical Association.

Growth factors-based therapy is widely used in orthopedics. Growth factor therapy has the potential to improve healing for a broad range of connective tissue injuries.

Growth Factors are found in all our Amniotic Injections and also available as a booster.

What benefits does regenerative growth factor treatments offer?

  • Powerful Treatment: Helps to relieve pain associated with joints, soft tissue and spinal injuries.
  • Minimally Invasive: 15-minute in office, single injection.
  • Alternative to Surgery:
  • Quick & Reduced Recovery Time: Return to everyday, low impact activities.
  • Safe, Non-steroidal: Helps recruit your body’s natural healing components including stem cells and growth factors to reconstruct and regenerate the injured tissues which are causing pain.

How does amniotic fluid injections work?

Amniotic Fluid takes advantage of the body’s ability to repair itself. With an amniotic fluid injection, your physician injects the amniotic fluid from donated amniotic tissue into your body. The amniotic fluid limits the expression of inflammatory cytokines and contains large amounts of hyaluronic acid that entrap inflammatory cells. Amniotic fluid goes far beyond the benefits of standard “injection therapy.”

While cortisone and other drugs only provide temporary pain relief, amniotic fluid helps modulate healing by promoting reconstruction rather than scar tissue formation. The growth factors in the amniotic fluid may recruit your body’s own stem cells, directly mitigating the repair and regeneration of healthy tissue. Additionally, amniotic fluid injections contain hyaluronic acid, helping to lubricate joints and tendons, easing the pain and helping restore mobility.

Are StemX regenerative Growth Factor treatments covered by insurance?

Yes, amniotic fluid injections may be covered by Medicare, Tricare, Blue Cross and other insurances. Please contact our office for your complimentary benefits review to determine your specific coverage.

Call 760 810 4104 to receive more information about StemX™ regenerative treatments.

Conditions treated

Regenerative Medicine. Data Outcome Study!

Our study is complete, and the data is in! Using Amniotic Membrane Allograft our patients have experienced an average of 53% improvement in mobility and pain relief after 12 weeks, 65% after 6 months and over 70%* after 1 year. Why risk invasive surgery – sign up for a free consultation to see if you are a candidate.

Contact us at 760 810 4104 to learn more!

(Study data based on knee treatments. 1-year outcome study is still in progress, with early results showing over 70% improvement in both mobility and pain relief! All results based on patient reported outcomes.)

The FACTS On Regenerative Medicine Vs. Surgery

Invasive Or Non-Invasive?

Have you been diagnosed with bone on bone osteoarthritis? Here are two of the major treatment options available. One is invasive and one non-invasive.

Testimonials

It’s been 5 and a half months. I’m doing well. My knees are pain free, the swelling is gone in both knees. There’s still a little fluid in the left knee, but that’ll go away with time. The spacing of the bones are fine and the cartilage is looking good. I’m doing well, I’m working out at the gym three days a week and my trainer is slowly getting me back into lower body exercises to accommodate the buildup of strength in my legs.

M. Phillips
My Knees Are Pain Free

It’s been 5 and a half months. I’m doing well. My knees are pain free, the swelling is gone in both knees. There’s still a little fluid in the left knee, but that’ll go away with time. The spacing of the bones are fine and the cartilage is looking good. I’m doing well, I’m working out at the gym three days a week and my trainer is slowly getting me back into lower body exercises to accommodate the buildup of strength in my legs.

R. Elkin
I Am Looking Forward To Getting My Life Back

X-rays and a MRI showed me to be bone-on-bone, and I had received a steroid injection – without any relief. It was difficult to walk up and down stairs and walk on uneven ground. Within 6 weeks, a sonogram showed space between the leg bones and it was more comfortable for me to walk and do stairs. I returned almost 8 months later for a follow-up – another sonogram showed still more space.

C. Norton
I am very happy that I made the decision

Dr. Kasendorf is absolutely incredible. After reviewing my case, he explained to me what the issues were and how stem cell treatments are helpful. Despite already reviewing my x-rays, he performed a diagnostic ultrasound at no extra charge! I am pleased to write that I am completely better (only 3 months after injection). I am thrilled that I was able to avoid surgery. Thank you Dr. Kasendorf and staff.

Sarah K.
Dr. Kasendorf is absolutely incredible!