Does Vitamin B12 Help With Weight Loss?

Nitrional Basics

By Dr. Samantha Larkin, ND – Associate Doctor and Manager of the Spark Health IV Program

Although there is no concrete research that B12 aids directly in weight loss, there is plenty of evidence to show that vitamin B12 deficiency can affect your overall health and wellbeing. 

Vitamin B12 aids in the conversion of food (fat, protein, and carbohydrates) into energy. Vitamin B12 may be depleted due to various factors, including irritable bowel disease, celiac disease, bariatric surgery, certain infections (such as H. Pylori), certain diets (vegetarian and vegan), and certain medications (such as oral contraceptives, PPIs, Metformin. antibiotics and corticosteroids). (3, 4, 5, 6)

Studies have shown that B12 deficiency is more common in those who are overweight or obese. (1,2)
It is unclear whether low B12 causes weight gain, but this research gives us insight into the micronutrient issues that may be related to a higher body mass index. 

Here at Spark Health, we love B12 and use a specific form known as methylcobalamin. Methylcobalamin is the form of vitamin B12 that can be used immediately without modification or conversion in the body. This is especially important for people with genetic mutations that make it difficult to activate compounds in the body by methylation.

Methylcobalamin is especially important for immune health. Supplementation of Methylcobalamin provides you with the defenders necessary to stay healthy, so you can keep up the good eating habits and exercise routines that make you successful in your weight loss journey. (7) 

How Spark Health Can Help.

Overall, vitamin B12 is helpful in keeping you healthy and active so you can reach your goals. Come to Spark Health today to try one of our B12 shots! We go above and beyond when formulating our shots, adding much more than just B12. If you are looking for a natural way to promote weight loss, we recommend trying our “Body Sculpt” Shot. This shot includes B12, L-carnitine and MIC. MIC (Methionine Inositol Choline) is known as the ultimate ‘weight loss’ nutrient combination, helping with fat burning and speeding up metabolism. Methionine, an essential amino acid, helps the liver break down fat. Inositol is critical for fat metabolism and fat-burning liver function, while choline regulates cholesterol and fat transport around the body, preventing fat from depositing in one place. If you prefer IV therapy, we recommend the Weight Loss Fast Bag, which features MIC, B vitamins, vitamin C, and minerals to get you feeling your best.

At Spark Health we have custom formulated many of our proprietary Vitamin Shots (Vitamin Injections) using B vitamins. Our Vitamin Shot Bar has a wide variety of B12 Shots to choose from… you can check out our extensive menu of shots at

For more information about our weight management offerings, give us at a call at 858-228-4188 or email us at

Spark is conveniently located so we can serve patients in San Diego, and all of North County such as Del Mar, Solana Beach, Rancho Santa Fe, Encinitas, Carlsbad, Escondido, San Marcos, and Poway. 

Thank you,

The Spark Team


1. Kaya et al. Obesity and insulin resistance associated with lower plasma vitamin B12 in PCOS. Reprod Biomed Online 2009; 19:721-6.

2. Baltac et al. Association of vitamin B12 with obesity, overweight, insulin resistance and metabolic syndrome, and body fat composition; primary care-based study. Med Glas (Zenica) 2013; 10(2):203-210

3. Aarts et al. The Gastric Sleeve: Losing Weight as Fast as Micronutrients? Obes Surg (2011) 21:207–211

4. Berenson, et al. Effect of hormonal contraceptives on vitamin B12 level and the association of the latter with bone mineral density. Contraception. 2012 November ; 86(5): 481–487

5. Zhao-Wei Ting, et al. Risk Factors of Vitamin B12 Deficiency in Patients Receiving MetforminArch Intern Med. 2006;166:1975-1979

6. Herrmann et al. Causes and early diagnosis of vitamin B12 deficiency. Dtsch Arztebl Int 2008; 105:680-5.

7. Tamura et al. Immunomodulation by vitamin B12: augmentation of CD8þT lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. (1999) Clin Exp Immu- nol116,28 – 32.